{ "resourceType": "Bundle", "id": "1", "meta": { "lastUpdated": "2025-04-16T08:07:52-06:00" }, "type": "searchset", "total": 2, "link": [ { "relation": "self", "url": "https://peoplepoweredmedicine.org/fhir/ResearchStudy" } ], "entry": [ { "fullUrl": "https://peoplepoweredmedicine.org/fhir/ResearchStudy/ppm-neer-research-study", "resource": { "id": "ppm-neer-research-study", "contained": [ { "id": "enrollmentgroup", "actual": false, "characteristic": [ { "code": { "coding": [ { "code": "exception-responder", "display": "Exceptional responder to cancer treatment", "system": "http://dbmi.hms.harvard.edu/fhir/eligibility" } ], "text": "Exceptional responder to cancer treatment" }, "exclude": false, "valueBoolean": true }, { "code": { "coding": [ { "code": "location-US", "display": "Residents of the United States", "system": "http://dbmi.hms.harvard.edu/fhir/eligibility" } ], "text": "Living in the United States" }, "exclude": false, "valueBoolean": true }, { "code": { "coding": [ { "code": "30525-0", "display": "Age 18 or older", "system": "http://loinc.org" } ], "text": "Age 18 or older" }, "exclude": false, "valueRange": { "low": { "value": 18 } } } ], "code": { "text": "We are looking for people who have had a unique response to cancer treatments that are not effective for most other patients. Previously, these patients were dismissed as outliers under the assumption that not much could be learned, but this thinking has recently reversed dramatically. Just as detailed study of rare diseases is illuminating basic biology in a way that informs larger disease populations, early study of exceptional responders is revealing new insights into tumor heterogeneity, overcoming heterogeneity-imposed therapeutic barriers, enabling more sophisticated pre-trial patient screening and enriching genomic profiling studies.", "_text": { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/rendering-xhtml", "valueString": "
We are looking for people who have had a unique response to cancer treatments that are not effective for most other patients. Previously, these patients were dismissed as outliers under the assumption that not much could be learned, but this thinking has recently reversed dramatically. Just as detailed study of rare diseases is illuminating basic biology in a way that informs larger disease populations, early study of exceptional responders is revealing new insights into tumor heterogeneity, overcoming heterogeneity-imposed therapeutic barriers, enabling more sophisticated pre-trial patient screening and enriching genomic profiling studies.
" } ] } }, "name": "PPM NEER Study Inclusion Criteria", "type": "person", "resourceType": "Group" }, { "id": "hms_organization", "alias": [ "Department of Biomedical Informatics, Harvard Medical School" ], "identifier": [ { "system": "https://hms.harvard.edu", "value": "Department of Biomedical Informatics" } ], "name": "Harvard Medical School", "resourceType": "Organization" } ], "contact": [ { "name": "Cassandra Perry", "telecom": [ { "system": "phone", "value": "(617)-432-5484" }, { "system": "email", "value": "ppm@hms.harvard.edu" } ] } ], "description": "This study looks at why certain individuals respond exceptionally well to cancer treatments.", "enrollment": [ { "reference": "#enrollmentgroup" } ], "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-neer-study" } ], "note": [ { "text": "
\n

“NEER” stands for Network of Enigmatic Exceptional Responders.

We are looking for people who have had a unique response to cancer treatments that are not effective for most other patients. Previously, these patients were dismissed as outliers under the assumption that not much could be learned, but this thinking has recently reversed dramatically.

Just as detailed study of rare diseases is illuminating basic biology in a way that informs larger disease populations, early study of exceptional responders is revealing new insights into tumor heterogeneity, overcoming heterogeneity-imposed therapeutic barriers, enabling more sophisticated pre-trial patient screening and enriching genomic profiling studies.

\n" }, { "text": "

Who Can Volunteer

Exceptional Responders may include:

\n" }, { "text": "

What to Expect

Here's what participation in the study involves.

Register via email and give a brief description of what makes you an exceptional responder to cancer treatment.

Complete an online questionnaire about your health history.

Give access to your medical records.

Collect blood, tumor, and stool (microbiome) samples for genetic testing.

\n\n" } ], "primaryPurposeType": { "coding": [ { "code": "screening", "display": "SCREENING", "system": "http://terminology.hl7.org/CodeSystem/research-study-prim-purp-type" }, { "code": "health-services-research", "display": "HEALTH-SERVICES-RESEARCH", "system": "http://terminology.hl7.org/CodeSystem/research-study-prim-purp-type" } ] }, "sponsor": { "reference": "#hms_organization" }, "status": "active", "title": "Network of Enigmatic Exceptional Responders (NEER) study", "resourceType": "ResearchStudy" } }, { "fullUrl": "https://peoplepoweredmedicine.org/fhir/ResearchStudy/ppmg-research-study", "resource": { "id": "ppmg-research-study", "contained": [ { "id": "enrollmentgroup", "actual": false, "characteristic": [ { "code": { "coding": [ { "code": "language-english", "display": "Comfortable in reading and writing in english", "system": "http://dbmi.hms.harvard.edu/fhir/eligibility" } ], "text": "Are you comfortable reading and writing in English on your iPhone?" }, "exclude": false, "valueBoolean": true }, { "code": { "coding": [ { "code": "location-US", "display": "Residents of the United States", "system": "http://dbmi.hms.harvard.edu/fhir/eligibility" } ], "text": "Do you live in the United States?" }, "exclude": false, "valueBoolean": true }, { "code": { "coding": [ { "code": "30525-0", "display": "Age between 40 and 75 years", "system": "http://loinc.org" } ], "text": "What is your age?" }, "exclude": false, "valueRange": { "high": { "value": 75 }, "low": { "value": 40 } } }, { "extension": [ { "url": "http://dbmi.hms.harvard.edu/fhir/group-learnMore", "valueString": "
  1. Open the Health app and tap the Summary tab.
  2. Tap your profile picture in the top right-hand corner.
  3. Under Features, tap Health Records, then tap Get Started. To add another provider, scroll down to Features, then tap Add Account.
  4. You'll be prompted to allow the Health app to use your location to find hospitals and health networks near you. Choose either Allow Once, Allow While Using App or Don't Allow.
  5. Search for yourcare provider / health system, then tap it.
  6. Under Available To Connect, choose an option.
  7. Sign in into the portal. You may be asked to save your password.
  8. Wait for your records to update. It may take a minute for your information to appear.
  9. Resume the second task to retrieve your health records
" } ], "code": { "coding": [ { "code": "link-ehrs", "display": "Willing to link and share health record from your iPhone's Health app", "system": "http://dbmi.hms.harvard.edu/fhir/eligibility" } ], "text": "Are you okay to link your iPhone's Health app with your electronic health record (EHR) of your care provider(s), if not already linked?\n\nThis is required to retrieve your EHR data for estimating risk of heart disease." }, "exclude": false, "valueBoolean": true }, { "code": { "coding": [ { "code": "78941-2", "display": "Having No history of heart attack, stroke or other heart related illness", "system": "http://loinc.org" } ], "text": "Have you ever had a heart attack, stroke or other heart related illness?" }, "exclude": false, "valueBoolean": false } ], "code": { "text": "This study is open to adults ages 40 and over who have not been diagnosed with atherosclerotic cardiovascular disease.\n\nParticipants must be residents of the United States.\n\nYou will need a compatible iPhone running iOS 14.0 or above and have connected the Apple Health app with your care-provider's patient portal." }, "name": "PPMG Study Inclusion Criteria", "type": "person", "resourceType": "Group" }, { "id": "hms-organization", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/Organization" ] }, "text": { "div": "
HMS-DBMI organization
", "status": "generated" }, "active": true, "address": [ { "city": "Boston", "country": "USA", "line": [ "10 Shattuck Street", "Suite 514" ], "postalCode": "02115", "state": "MA", "type": "both", "use": "work" } ], "alias": [ "DBMI" ], "name": "Department of Biomedical Informatics, Harvard Medical School", "telecom": [ { "system": "phone", "use": "work", "value": "+1‑617‑432‑2144" }, { "system": "url", "use": "work", "value": "https://dbmi.hms.harvard.edu" } ], "type": [ { "coding": [ { "code": "edu", "display": "Educational Institute", "system": "http://terminology.hl7.org/CodeSystem/organization-type" } ], "text": "Department of Biomedical Informatics at Harvard Medical School" } ], "resourceType": "Organization" }, { "id": "PI-PeopleHeartStudy", "text": { "div": "
Dr. Isaac Kohane, MD, PhD
", "status": "generated" }, "active": true, "address": [ { "city": "Boston", "country": "USA", "line": [ "Countway Library of Medicine, Suite 514", "10 Shattuck Street" ], "postalCode": "02115", "state": "MA", "type": "both", "use": "work" } ], "name": [ { "family": "Kohane", "given": [ "Isaac", "Samuel" ], "prefix": [ "Dr." ], "suffix": [ "MD", "PhD" ], "use": "official" } ], "qualification": [ { "code": { "text": "Doctor of Medicine" }, "identifier": [ { "system": "http://www.abms.org/cert", "value": "MD" } ] }, { "code": { "text": "Doctor of Philosophy" } } ], "resourceType": "Practitioner" }, { "id": "definition-demographic-survey", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition of a task to take a questionnaire for demographic information
", "status": "generated" }, "description": "Definition of a task to take a questionnaire for demographic information", "experimental": true, "kind": "ServiceRequest", "name": "ActivityDefinition_DemographicSurvey", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-demographic-survey", "type": "depends-on" } ], "status": "active", "subtitle": "Tell us more about yourself to help estimate your risk of developing heart disease", "title": "Demographic information", "url": "https://peoplepoweredmedicine.org/fhir/phs-activitiydefinition-task1", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-demographic-survey", "text": { "div": "
This is a demographic survey as part of the People Heart Study from Harvard Medical School
", "status": "generated" }, "code": [ { "code": "demographic-survey", "display": "Demographic survey", "system": "http://dbmi.hms.harvard.edu" } ], "date": "2020-11", "description": "Survey for the first task of People Heart Study", "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "demographic-survey" } ], "item": [ { "linkId": "notice", "text": "In this survey, we will ask for your demographic information (age, gender and race), required to estimate your risk of developing heart disease risk.", "type": "display" }, { "code": [ { "code": "21112-8", "display": "Birth Date", "system": "http://loinc.org" } ], "initial": [ { "valueDate": "1982-01-01" } ], "linkId": "/54126-8/21112-8", "required": true, "text": "Please enter your birth date.", "type": "date" }, { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl", "valueCodeableConcept": { "coding": [ { "code": "drop-down", "display": "Drop down", "system": "http://hl7.org/fhir/questionnaire-item-control" } ] } } ], "answerOption": [ { "valueCoding": { "code": "LA2-8", "display": "Male", "system": "http://loinc.org" } }, { "valueCoding": { "code": "LA3-6", "display": "Female", "system": "http://loinc.org" } } ], "code": [ { "code": "54131-8", "display": "Gender", "system": "http://loinc.org" } ], "linkId": "/54126-8/54131-8", "required": true, "text": "Gender", "type": "choice" }, { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-itemControl", "valueCodeableConcept": { "coding": [ { "code": "drop-down", "display": "Drop down", "system": "http://hl7.org/fhir/questionnaire-item-control" } ] } }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-instruction", "valueString": "Race is used for estimating risk of developing heart disease. While the ACC/AHA guideline considers data from African-American and White populations, we hope to collect race to better understand study participants." } ], "answerOption": [ { "valueCoding": { "code": "LA6155-1", "display": "American Indian or Alaska Native", "system": "http://loinc.org" } }, { "valueCoding": { "code": "LA6156-9", "display": "Asian", "system": "http://loinc.org" } }, { "valueCoding": { "code": "LA6162-7", "display": "Black or African-American", "system": "http://loinc.org" } }, { "valueCoding": { "code": "LA6214-6", "display": "Hispanic or Latino", "system": "http://loinc.org" } }, { "valueCoding": { "code": "LA6266-6", "display": "Native Hawaiian or Pacific Islander", "system": "http://loinc.org" } }, { "valueCoding": { "code": "LA4457-3", "display": "White", "system": "http://loinc.org" } }, { "valueCoding": { "code": "LA46-8", "display": "Other", "system": "http://loinc.org" } }, { "valueCoding": { "code": "LA4489-6", "display": "Unknown", "system": "http://loinc.org" } } ], "code": [ { "code": "54134-2", "display": "Race", "system": "http://loinc.org" } ], "linkId": "race", "required": true, "text": "Race", "type": "choice" } ], "name": "Demographic_Survey", "publisher": "Harvard Medical School", "purpose": "This survey is used for the People Heart study from Harvard Medical School", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Demographic Survey", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "AD-HealthRecords", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition of a health record retrieval task using SMART Markers software
", "status": "generated" }, "code": { "coding": [ { "code": "healthrecords", "system": "http://smartmarkers.smarthealthit.org/vs-instruments" } ] }, "description": "Definition of a task to request health records from the Apple Health App", "experimental": true, "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "healthrecords" } ], "jurisdiction": [ { "coding": [ { "code": "US", "system": "urn:iso:std:iso:3166" } ] } ], "kind": "Task", "name": "ActivityDefinition_Task2_HealthRecords", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Task for participant to complete as part of a study activity for People Heart study", "status": "active", "subtitle": "Link your iPhone Health app with your medical records to allow access to your test results and medical history.", "title": "Your Health records", "url": "https://peoplepoweredmedicine.org/fhir/ActivityDefinition/task2", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "phs-conditions", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareablevalueset" ] }, "text": { "div": "
List of conditions as part of people heart study
", "status": "generated" }, "compose": { "include": [ { "concept": [ { "code": "38341003", "display": "Hypertension" }, { "code": "44054006", "display": "Diabetes mellitus type 2" } ], "system": "http://snomed.info/sct" } ] }, "description": "Diagnosis codes for Hypertension and Type2 Diabetes mellitus", "experimental": true, "name": "Conditions_list_People_Heart_Study", "publisher": "Harvard Medical School", "status": "draft", "title": "List of conditions for People Heart Study", "url": "https://peoplepoweredmedicine.org/fhir/ValueSet/phs-conditions", "version": "1.0", "resourceType": "ValueSet" }, { "id": "phs-medications", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareablevalueset" ] }, "text": { "div": "
List of medications required for people heart study
", "status": "generated" }, "compose": { "include": [ { "concept": [ { "code": "262095", "display": "atorvastatin 80 MG Oral Tablet [Lipitor]" }, { "code": "617314", "display": "atorvastatin 10 MG Oral Tablet [Lipitor]" }, { "code": "617318", "display": "atorvastatin 20 MG Oral Tablet [Lipitor]" }, { "code": "617320", "display": "atorvastatin 40 MG Oral Tablet [Lipitor]" }, { "code": "750199", "display": "amlodipine 10 MG / atorvastatin 10 MG Oral Tablet [Caduet]" }, { "code": "750203", "display": "amlodipine 10 MG / atorvastatin 20 MG Oral Tablet [Caduet]" }, { "code": "750207", "display": "amlodipine 10 MG / atorvastatin 40 MG Oral Tablet [Caduet]" }, { "code": "750211", "display": "amlodipine 10 MG / atorvastatin 80 MG Oral Tablet [Caduet]" }, { "code": "750215", "display": "amlodipine 2.5 MG / atorvastatin 40 MG Oral Tablet [Caduet]" }, { "code": "750227", "display": "amlodipine 5 MG / atorvastatin 10 MG Oral Tablet [Caduet]" }, { "code": "750231", "display": "amlodipine 5 MG / atorvastatin 20 MG Oral Tablet [Caduet]" }, { "code": "750235", "display": "amlodipine 5 MG / atorvastatin 40 MG Oral Tablet [Caduet]" }, { "code": "750239", "display": "amlodipine 5 MG / atorvastatin 80 MG Oral Tablet [Caduet]" }, { "code": "259255", "display": "atorvastatin 80 MG Oral Tablet" }, { "code": "404011", "display": "amlodipine 5 MG / atorvastatin 80 MG Oral Tablet" }, { "code": "404013", "display": "amlodipine 10 MG / atorvastatin 80 MG Oral Tablet" }, { "code": "597967", "display": "amlodipine 10 MG / atorvastatin 20 MG Oral Tablet" }, { "code": "597971", "display": "amlodipine 2.5 MG / atorvastatin 10 MG Oral Tablet" }, { "code": "597974", "display": "amlodipine 2.5 MG / atorvastatin 20 MG Oral Tablet" }, { "code": "597977", "display": "amlodipine 5 MG / atorvastatin 10 MG Oral Tablet" }, { "code": "597980", "display": "amlodipine 5 MG / atorvastatin 20 MG Oral Tablet" }, { "code": "597984", "display": "amlodipine 5 MG / atorvastatin 40 MG Oral Tablet" }, { "code": 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"display": "lovastatin 40 MG Oral Tablet" }, { "code": "359731", "display": "24 HR lovastatin 40 MG Extended Release Oral Tablet" }, { "code": "433849", "display": "24 HR lovastatin 20 MG Extended Release Oral Tablet" }, { "code": "582041", "display": "24 HR lovastatin 20 MG / niacin 1000 MG Extended Release Oral Tablet" }, { "code": "582042", "display": "24 HR lovastatin 20 MG / niacin 500 MG Extended Release Oral Tablet" }, { "code": "582043", "display": "24 HR lovastatin 20 MG / niacin 750 MG Extended Release Oral Tablet" }, { "code": "729605", "display": "lovastatin 40 MG / niacin 1000 MG Oral Tablet" }, { "code": "359732", "display": "24 HR lovastatin 60 MG Extended Release Oral Tablet" }, { "code": "904668", "display": "{30 (aspirin 81 MG Oral Tablet) / 30 (pravastatin sodium 40 MG Oral Tablet) } Pack" }, { "code": "904664", "display": "{30 (aspirin 325 MG Oral Tablet) / 30 (pravastatin sodium 80 MG Oral Tablet) } Pack" }, { "code": "904460", "display": "pravastatin sodium 10 MG 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Tablet [Zypitamag]" }, { "code": "861643", "display": "pitavastatin calcium 1 MG Oral Tablet" }, { "code": "861648", "display": "pitavastatin calcium 2 MG Oral Tablet" }, { "code": "861652", "display": "pitavastatin calcium 4 MG Oral Tablet" }, { "code": "2001254", "display": "pitavastatin magnesium 1 MG Oral Tablet" }, { "code": "2001262", "display": "pitavastatin magnesium 2 MG Oral Tablet" }, { "code": "2001266", "display": "pitavastatin magnesium 4 MG Oral Tablet" }, { "code": "1944262", "display": "simvastatin 4 MG/ML Oral Suspension [Flolipid]" }, { "code": "1944266", "display": "simvastatin 8 MG/ML Oral Suspension [Flolipid]" }, { "code": "104490", "display": "simvastatin 10 MG Oral Tablet [Zocor]" }, { "code": "104491", "display": "simvastatin 20 MG Oral Tablet [Zocor]" }, { "code": "152923", "display": "simvastatin 40 MG Oral Tablet [Zocor]" }, { "code": "208220", "display": "simvastatin 5 MG Oral Tablet [Zocor]" }, { "code": "213319", "display": "simvastatin 80 MG Oral Tablet [Zocor]" }, { "code": "1245420", "display": "ezetimibe 10 MG / simvastatin 10 MG Oral Tablet [Vytorin]" }, { "code": "1245430", "display": "ezetimibe 10 MG / simvastatin 20 MG Oral Tablet [Vytorin]" }, { "code": "1245441", "display": "ezetimibe 10 MG / simvastatin 40 MG Oral Tablet [Vytorin]" }, { "code": "1245449", "display": "ezetimibe 10 MG / simvastatin 80 MG Oral Tablet [Vytorin]" }, { "code": "1944264", "display": "simvastatin 8 MG/ML Oral Suspension" }, { "code": "198211", "display": "simvastatin 40 MG Oral Tablet" }, { "code": "200345", "display": "simvastatin 80 MG Oral Tablet" }, { "code": "312961", "display": "simvastatin 20 MG Oral Tablet" }, { "code": "314231", "display": "simvastatin 10 MG Oral Tablet" }, { "code": "476345", "display": "ezetimibe 10 MG / simvastatin 10 MG Oral Tablet" }, { "code": "476349", "display": "ezetimibe 10 MG / simvastatin 20 MG Oral Tablet" }, { "code": "476350", "display": "ezetimibe 10 MG / simvastatin 40 MG Oral Tablet" }, { "code": "476351", "display": "ezetimibe 10 MG / simvastatin 80 MG Oral Tablet" }, { "code": "757702", "display": "simvastatin 10 MG Disintegrating Oral Tablet" }, { "code": "757703", "display": "simvastatin 20 MG Disintegrating Oral Tablet" }, { "code": "757704", "display": "simvastatin 40 MG Disintegrating Oral Tablet" }, { "code": "757705", "display": "simvastatin 80 MG Disintegrating Oral Tablet" }, { "code": "761907", "display": "24 HR niacin 1000 MG / simvastatin 20 MG Extended Release Oral Tablet" }, { "code": "761909", "display": "24 HR niacin 500 MG / simvastatin 20 MG Extended Release Oral Tablet" }, { "code": "762970", "display": "24 HR niacin 750 MG / simvastatin 20 MG Extended Release Oral Tablet" }, { "code": "312962", "display": "simvastatin 5 MG Oral Tablet" }, { "code": "1790679", "display": "simvastatin 4 MG/ML Oral Suspension" }, { "code": "103918", "display": "Lescol 20 MG Oral Capsule" }, { "code": "103919", "display": "Lescol 40 MG Oral Capsule" }, { "code": "687048", "display": "24 HR fluvastatin 80 MG Extended Release Oral Tablet [Lescol]" }, { "code": "310404", "display": "fluvastatin 20 MG Oral Capsule" }, { "code": "310405", "display": "fluvastatin 40 MG Oral Capsule" }, { "code": "360507", "display": "24 HR fluvastatin 80 MG Extended Release Oral Tablet" }, { "code": "316672", "display": "simvastatin 10 MG" }, { "code": "1422096", "display": "atorvastatin 40 MG / ezetimibe 10 MG Oral Tablet" }, { "code": "859751", "display": "rosuvastatin calcium 20 MG Oral Tablet" }, { "code": "197903", "display": "lovastatin 10 MG Oral Tablet" }, { "code": "904467", "display": "pravastatin sodium 20 MG Oral Tablet" }, { "code": "1422086", "display": "atorvastatin 10 MG / ezetimibe 10 MG Oral Tablet" }, { "code": "597980", "display": "amlodipine 5 MG / atorvastatin 20 MG Oral Tablet" }, { "code": "259255", "display": "atorvastatin 80 MG Oral Tablet" }, { "code": "83367", "display": "atorvastatin" }, { "code": "36567", "display": "simvastatin" }, { "code": "104375", "display": "lisinopril 2.5 MG Oral Tablet [Zestril]" }, { "code": "104376", "display": "lisinopril 5 MG Oral Tablet [Zestril]" }, { "code": "104377", "display": "lisinopril 10 MG Oral Tablet [Zestril]" }, { "code": "104378", "display": "lisinopril 20 MG Oral Tablet [Zestril]" }, { "code": "206771", "display": "lisinopril 40 MG Oral Tablet [Zestril]" }, { "code": "213482", "display": "lisinopril 30 MG Oral Tablet [Zestril]" }, { "code": "206764", "display": "lisinopril 5 MG Oral Tablet [Prinivil]" }, { "code": "206765", "display": "lisinopril 10 MG Oral Tablet [Prinivil]" }, { "code": "206766", "display": "lisinopril 20 MG Oral Tablet [Prinivil]" }, { "code": "207965", "display": "hydrochlorothiazide 25 MG / lisinopril 20 MG Oral Tablet [Prinzide]" }, { "code": "823971", "display": "hydrochlorothiazide 25 MG / lisinopril 20 MG Oral Tablet [Zestoretic]" }, { "code": "823982", "display": "hydrochlorothiazide 12.5 MG / lisinopril 20 MG Oral Tablet [Zestoretic]" }, { "code": "823986", "display": "hydrochlorothiazide 12.5 MG / lisinopril 10 MG Oral Tablet [Zestoretic]" }, { "code": "1806890", "display": "lisinopril 1 MG/ML Oral Solution [Qbrelis]" }, { "code": "197884", "display": "lisinopril 40 MG Oral Tablet" }, { "code": "197885", "display": "hydrochlorothiazide 12.5 MG / lisinopril 10 MG Oral Tablet" }, { "code": "197886", "display": "hydrochlorothiazide 12.5 MG / lisinopril 20 MG Oral Tablet" }, { "code": "197887", "display": "hydrochlorothiazide 25 MG / lisinopril 20 MG Oral Tablet" }, { "code": "205326", "display": "lisinopril 30 MG Oral Tablet" }, { "code": "311353", "display": "lisinopril 2.5 MG Oral Tablet" }, { "code": "311354", "display": "lisinopril 5 MG Oral Tablet" }, { "code": "314076", "display": "lisinopril 10 MG Oral Tablet" }, { "code": "314077", "display": "lisinopril 20 MG Oral Tablet" }, { "code": "1806884", "display": "lisinopril 1 MG/ML Oral Solution" }, { "code": "352304", "display": "ezetimibe 10 MG Oral Tablet [Zetia]" }, { "code": "2283236", "display": "bempedoic acid 180 MG / ezetimibe 10 MG Oral Tablet [Nexlizet]" }, { "code": "349556", "display": "ezetimibe 10 MG Oral Tablet" }, { "code": "2283230", "display": "bempedoic acid 180 MG / ezetimibe 10 MG Oral Tablet" }, { "code": "540281", "display": "fenofibrate 145 MG Oral Tablet [Tricor]" }, { "code": "544518", "display": "fenofibrate 48 MG Oral Tablet [Tricor]" }, { "code": "578797", "display": "fenofibrate 130 MG Oral Capsule [Antara]" }, { "code": "578799", "display": "fenofibrate 43 MG Oral Capsule [Antara]" }, { "code": "583096", "display": "fenofibrate 160 MG Oral Tablet [Triglide]" }, { "code": "1442165", "display": "fenofibrate 30 MG Oral Capsule [Antara]" }, { "code": "1442170", "display": "fenofibrate 90 MG Oral Capsule [Antara]" }, { "code": "702055", "display": "fenofibrate 150 MG Oral Capsule [Lipofen]" }, { "code": "702169", "display": "fenofibrate 50 MG Oral Capsule [Lipofen]" }, { "code": "763250", "display": "fenofibrate 120 MG Oral Tablet [Fenoglide]" }, { "code": "763252", "display": "fenofibrate 40 MG Oral Tablet [Fenoglide]" }, { "code": "828377", "display": "TRILIPIX 135 MG DELAYED RELEASE ORAL CAPSULE" }, { "code": "828381", "display": "TRILIPIX 45 MG DELAYED RELEASE ORAL CAPSULE" }, { "code": "860884", "display": "FIBRICOR 105 MG ORAL TABLET" }, { "code": "860888", "display": "fenofibric acid 35 MG Oral Tablet [Fibricor]" }, { "code": "141916", "display": "fenofibrate 100 MG Oral Capsule" }, { "code": "200311", "display": "fenofibrate 67 MG Oral Capsule" }, { "code": "310288", "display": "fenofibrate 134 MG Oral Capsule" }, { "code": "310289", "display": "fenofibrate 200 MG Oral Capsule" }, { "code": "349287", "display": "fenofibrate 160 MG Oral Tablet" }, { "code": "351133", "display": "fenofibrate 54 MG Oral Tablet" }, { "code": "389191", "display": "fenofibrate 267 MG Oral Capsule" }, { "code": "477560", "display": "fenofibrate 145 MG Oral Tablet" }, { "code": "477562", "display": "fenofibrate 48 MG Oral Tablet" }, { "code": "483425", "display": "fenofibrate 130 MG Oral Capsule" }, { "code": "483427", "display": "fenofibrate 43 MG Oral Capsule" }, { "code": "483429", "display": "fenofibrate 87 MG Oral Capsule" }, { "code": "577031", "display": "fenofibrate 50 MG Oral Tablet" }, { "code": "616853", "display": "fenofibrate 50 MG Oral Capsule" }, { "code": "616852", "display": "fenofibrate 150 MG Oral Capsule" }, { "code": "749802", "display": "fenofibrate 120 MG Oral Tablet" }, { "code": "749804", "display": "fenofibrate 40 MG Oral Tablet" }, { "code": "828373", "display": "fenofibric acid 135 MG Delayed Release Oral Capsule" }, { "code": "828379", "display": "fenofibric acid 45 MG Delayed Release Oral Capsule" }, { "code": "860880", "display": "fenofibric acid 105 MG Oral Tablet" }, { "code": "860886", "display": "fenofibric acid 35 MG Oral Tablet" }, { "code": "1442163", "display": "fenofibrate 30 MG Oral Capsule" }, { "code": "1442168", "display": "fenofibrate 90 MG Oral Capsule" }, { "code": "205751", "display": "gemfibrozil 600 MG Oral Tablet [Lopid]" }, { "code": "315106", "display": "gemfibrozil 300 MG Oral Capsule" }, { "code": "310459", "display": "gemfibrozil 600 MG Oral Tablet" }, { "code": "433853", "display": "24 HR bezafibrate 400 MG Extended Release Oral Tablet" }, { "code": "199700", "display": "bezafibrate 200 MG Oral Tablet" }, { "code": "848949", "display": "cholestyramine resin 4000 MG Powder for Oral Suspension [Questran]" }, { "code": "1801280", "display": "Sugar-Free cholestyramine resin 4000 MG Powder for Oral Suspension [Questran]" }, { "code": "848951", "display": "Sugar-Free cholestyramine resin 4000 MG Powder for Oral Suspension [Prevalite]" }, { "code": "848943", "display": "cholestyramine resin 4000 MG Powder for Oral Suspension" }, { "code": "1801279", "display": "Sugar-Free cholestyramine resin 4000 MG Powder for Oral Suspension" }, { "code": "1048447", "display": "colestipol hydrochloride 1000 MG Oral Tablet [Colestid]" }, { "code": "1048452", "display": "Colestid 5 GM Granules For Oral Suspension" }, { "code": "1048445", "display": "colestipol hydrochloride 1000 MG Oral Tablet" }, { "code": "1048450", "display": "colestipol HCl 5 GM Granules For Oral Suspension" }, { "code": "866907", "display": "colesevelam hydrochloride 3750 MG Powder for Oral Suspension [Welchol]" }, { "code": "866912", "display": "colesevelam hydrochloride 625 MG Oral Tablet [Welchol]" }, { "code": "866910", "display": "colesevelam hydrochloride 625 MG Oral Tablet" }, { "code": "866900", "display": "colesevelam hydrochloride 1875 MG Powder for Oral Suspension" }, { "code": "866905", "display": "colesevelam hydrochloride 3750 MG Powder for Oral Suspension" }, { "code": "1102207", "display": "{6 (ascorbic acid 100 MG / biotin 0.3 MG / calcium carbonate 100 MG / calcium pantothenate 7 MG / folic acid 1 MG / niacin 25 MG / pyridoxine hydrochloride 30 MG / riboflavin 5 MG / succinic acid 150 MG / thiamine hydrochloride 5 MG / vitamin B12 0.01 MG Oral Tablet) / 24 (ascorbic acid 100 MG / biotin 0.3 MG / calcium pantothenate 0.3 MG / ferrous bisglycinate 65 MG / folic acid 1 MG / formic acid 155 MG / iron-dextran complex 65 MG / niacin 25 MG / pyridoxine hydrochloride 30 MG / riboflavin 5 MG / thiamine hydrochloride 5 MG / vitamin B12 0.01 MG Oral Tablet [Irospan Tablet]) } Pack [Irospan 24/6 Kit]" }, { "code": "1102202", "display": "ascorbic acid 100 MG / biotin 0.3 MG / calcium carbonate 100 MG / calcium pantothenate 7 MG / folic acid 1 MG / niacin 25 MG / pyridoxine HCl 30 MG / riboflavin 5 MG / succinic acid 150 MG / thiamine HCl 5 MG / vitamin B 12 10 MCG Oral Tablet (6) / ascorbic acid 100 MG / biotin 0.3 MG / calcium pantothenate 0.3 MG / ferrous bisglycinate 65 MG / folic acid 1 MG / formic acid 155 MG / iron-dextran complex 65 MG / niacin 25 MG / pyridoxine HCl 30 MG / riboflavin 5 MG / thiamine HCl 5 MG / vitamin B 12 10 MCG Oral Tablet (24) Pack" }, { "code": "1087302", "display": "ascorbic acid 40 MG / ferrous fumarate 62.5 MG / folic acid 1 MG / niacin 3 MG / polysaccharide iron complex 62.5 MG Oral Capsule [Folivane-F]" }, { "code": "1087623", "display": "ascorbic acid 100 MG / biotin 0.15 MG / calcium pantothenate 5 MG / folic acid 1 MG / niacin 20 MG / pyridoxine 10 MG / riboflavin 1.7 MG / thiamine mononitrate 1.5 MG / vitamin B12 0.006 MG Oral Capsule [Nephrocaps]" }, { "code": "1102206", "display": "ascorbic acid 100 MG / biotin 0.3 MG / calcium pantothenate 0.3 MG / ferrous bisglycinate 65 MG / folic acid 1 MG / formic acid 155 MG / iron-dextran complex 65 MG / niacin 25 MG / pyridoxine hydrochloride 30 MG / riboflavin 5 MG / thiamine hydrochloride 5 MG / vitamin B12 0.01 MG Oral Tablet [Irospan Tablet]" }, { "code": "1119573", "display": "ascorbic acid 30 MG / cholecalciferol 1000 UNT / cuprous oxide 2 MG / folic acid 1 MG / magnesium oxide 20 MG / niacin 15 MG / polysaccharide iron complex 29 MG / potassium iodide 0.15 MG / pyridoxine hydrochloride 2.5 MG / riboflavin 1.8 MG / thiamine mononitrate 1.6 MG / vitamin A 1100 UNT / vitamin B12 0.012 MG / vitamin E 20 UNT / zinc oxide 25 MG Oral Capsule [Vitafol-One]" }, { "code": "207662", "display": "niacin 500 MG Extended Release Oral Tablet [B3-500-Gr]" }, { "code": "211684", "display": "niacin 50 MG Oral Tablet [B-3-50]" }, { "code": "311944", "display": "niacin 500 MG Oral Tablet [Niacor]" }, { "code": "876861", "display": "ascorbic acid 35 MG/ML / cholecalciferol 0.01 MG/ML / niacin 8 MG/ML / riboflavin 0.6 MG/ML / thiamine 0.5 MG/ML / vitamin A 0.45 MG/ML / vitamin B12 0.002 MG/ML / vitamin B6 0.4 MG/ML / vitamin E 2.25 MG/ML Oral Solution [Poly-Vi-Sol]" }, { "code": "876866", "display": "ascorbic acid 35 MG/ML / cholecalciferol 0.01 MG/ML / ferrous sulfate 50 MG/ML / niacin 8 MG/ML / riboflavin 0.6 MG/ML / thiamine 0.5 MG/ML / vitamin A 0.45 MG/ML / vitamin B6 0.4 MG/ML / vitamin E 2.25 MG/ML Oral Solution [Poly-Vi-Sol with Iron]" }, { "code": "212579", "display": "niacin 750 MG Extended Release Oral Tablet [Slo-Niacin]" }, { "code": "260852", "display": "niacin 500 MG Extended Release Oral Tablet [Slo-Niacin]" }, { "code": "647346", "display": "niacin 250 MG Extended Release Oral Tablet [Slo-Niacin]" }, { "code": "1098135", "display": "24 HR niacin 1000 MG Extended Release Oral Tablet [Niaspan]" }, { "code": "1098142", "display": "24 HR niacin 500 MG Extended Release Oral Tablet [Niaspan]" }, { "code": "1098144", "display": "24 HR niacin 750 MG Extended Release Oral Tablet [Niaspan]" }, { "code": "1428828", "display": "ascorbic acid 60 MG / cholecalciferol 0.01 MG / folic acid 0.3 MG / niacin 13.5 MG / riboflavin 1.2 MG / sodium fluoride 2.2 MG / thiamine 1.05 MG / vitamin A 0.75 MG / vitamin B12 0.0045 MG / vitamin B6 1.05 MG / vitamin E 15 UNT Chewable Tablet [MVC-Fluoride]" }, { "code": "1314672", "display": "ascorbic acid 210 MG / biotin 0.3 MG / calcium pantothenate 7 MG / copper sulfate 0.8 MG / ferrous fumarate 130 MG / folic acid 1 MG / magnesium sulfate 6.9 MG / manganese sulfate 1.3 MG / niacin 20 MG / polysaccharide iron complex 92.4 MG / pyridoxine hydrochloride 25 MG / riboflavin 5 MG / thiamine mononitrate 5 MG / vitamin B12 0.01 MG / zinc sulfate 18.2 MG Oral Capsule [Concept OB]" }, { "code": "2121691", "display": "ENDUR-AMIDE 500 MG Extended Release Oral Tablet" }, { "code": "1088779", "display": "niacin 500 MG Extended Release Oral Tablet [Endur-Acin]" }, { "code": "2001472", "display": "niacin 250 MG Extended Release Oral Tablet [Endur-Acin]" }, { "code": "2001474", "display": "niacin 750 MG Extended Release Oral Tablet [Endur-Acin]" }, { "code": "2001480", "display": "niacin 750 MG Extended Release Oral Tablet [Endur-Amide]" }, { "code": "2001492", "display": "niacin 500 MG / pantethine 200 MG Extended Release Oral Tablet [Endur-Thine]" }, { "code": "1098134", "display": "24 HR niacin 1000 MG Extended Release Oral Tablet" }, { "code": "1098141", "display": "24 HR niacin 500 MG Extended Release Oral Tablet" }, { "code": "1098143", "display": "24 HR niacin 750 MG Extended Release Oral Tablet" }, { "code": "198024", "display": "niacin 500 MG Oral Tablet" }, { "code": "198759", "display": "niacin 100 MG Oral Tablet" }, { "code": "198760", "display": "niacin 50 MG Oral Tablet" }, { "code": "199143", "display": "niacin 250 MG Oral Tablet" }, { "code": "200015", "display": "inositol 100 MG / niacin 400 MG Oral Capsule" }, { "code": "243782", "display": "niacin 1000 MG Oral Tablet" }, { "code": "247747", "display": "niacin 500 MG Oral Capsule" }, { "code": "311951", "display": "niacin 125 MG Extended Release Oral Capsule" }, { "code": "311955", "display": "niacin 250 MG Extended Release Oral Tablet" }, { "code": "311959", "display": "niacin 500 MG Extended Release Oral Capsule" }, { "code": "311960", "display": "niacin 500 MG Extended Release Oral Tablet" }, { "code": "311963", "display": "niacin 750 MG Extended Release Oral Tablet" }, { "code": "314131", "display": "niacin 250 MG Extended Release Oral Capsule" }, { "code": "391943", "display": "niacin 750 MG Oral Tablet" }, { "code": "796544", "display": "inositol 141 MG / niacin 500 MG Oral Capsule" }, { "code": "848987", "display": "inositol 152 MG / niacin 500 MG Oral Capsule" }, { "code": "881376", "display": "inositol niacinate 211.5 MG / niacin 750 MG Oral Capsule" }, { "code": "1539267", "display": "inositol 125 MG / niacin 500 MG Oral Tablet" }, { "code": "2001486", "display": "niacin 500 MG / pantethine 200 MG Extended Release Oral Tablet" }, { "code": "1102196", "display": "ascorbic acid 100 MG / biotin 0.3 MG / calcium pantothenate 0.3 MG / ferrous bisglycinate 65 MG / folic acid 1 MG / formic acid 155 MG / iron-dextran complex 65 MG / niacin 25 MG / pyridoxine hydrochloride 30 MG / riboflavin 5 MG / thiamine hydrochloride 5 MG / vitamin B12 0.01 MG Oral Tablet" }, { "code": "1102201", "display": "ascorbic acid 100 MG / biotin 0.3 MG / calcium carbonate 100 MG / calcium pantothenate 7 MG / folic acid 1 MG / niacin 25 MG / pyridoxine hydrochloride 30 MG / riboflavin 5 MG / succinic acid 150 MG / thiamine hydrochloride 5 MG / vitamin B12 0.01 MG Oral Tablet" }, { "code": "283092", "display": "niacin 0.2 MG / riboflavin 0.02 MG / thiamine 0.06 MG Oral Tablet" }, { "code": "311948", "display": "niacin 0.15 MG / riboflavin 0.02 MG / thiamine 0.06 MG Oral Tablet" }, { "code": "891522", "display": "ascorbic acid 100 MG / biotin 0.15 MG / calcium pantothenate 5 MG / folic acid 1 MG / niacin 20 MG / pyridoxine 10 MG / riboflavin 1.7 MG / thiamine mononitrate 1.5 MG / vitamin B12 0.006 MG Oral Capsule" }, { "code": "1314666", "display": "ascorbic acid 210 MG / biotin 0.3 MG / calcium pantothenate 7 MG / copper sulfate 0.8 MG / ferrous fumarate 130 MG / folic acid 1 MG / magnesium sulfate 6.9 MG / manganese sulfate 1.3 MG / niacin 20 MG / polysaccharide iron complex 92.4 MG / pyridoxine hydrochloride 25 MG / riboflavin 5 MG / thiamine mononitrate 5 MG / vitamin B12 0.01 MG / zinc sulfate 18.2 MG Oral Capsule" }, { "code": "1119569", "display": "ascorbic acid 30 MG / cholecalciferol 1000 UNT / cuprous oxide 2 MG / folic acid 1 MG / magnesium oxide 20 MG / niacin 15 MG / polysaccharide iron complex 29 MG / potassium iodide 0.15 MG / pyridoxine hydrochloride 2.5 MG / riboflavin 1.8 MG / thiamine mononitrate 1.6 MG / vitamin A 1100 UNT / vitamin B12 0.012 MG / vitamin E 20 UNT / zinc oxide 25 MG Oral Capsule" }, { "code": "1364854", "display": "ascorbic acid 60 MG / cholecalciferol 0.01 MG / folic acid 0.3 MG / niacin 13.5 MG / riboflavin 1.2 MG / sodium fluoride 1.1 MG / thiamine 1.05 MG / vitamin A 0.75 MG / vitamin B12 0.0045 MG / vitamin B6 1.05 MG / vitamin E 6.75 MG Chewable Tablet" }, { "code": "1364855", "display": "ascorbic acid 60 MG / cholecalciferol 0.01 MG / folic acid 0.3 MG / niacin 13.5 MG / riboflavin 1.2 MG / sodium fluoride 2.2 MG / thiamine 1.05 MG / vitamin A 0.75 MG / vitamin B12 0.0045 MG / vitamin B6 1.05 MG / vitamin E 15 UNT Chewable Tablet" }, { "code": "1235389", "display": "ascorbic acid 60 MG / cholecalciferol 0.01 MG / folic acid 0.3 MG / niacin 13.5 MG / riboflavin 1.2 MG / sodium fluoride 0.55 MG / thiamine 1.05 MG / vitamin A 0.75 MG / vitamin B12 0.0045 MG / vitamin B6 1.05 MG / vitamin E 6.75 MG Chewable Tablet" }, { "code": "1241896", "display": "niacin 15 MG / pantothenic acid 5 MG / riboflavin 2 MG / thiamine 2 MG / vitamin B12 0.002 MG / vitamin B6 2 MG Oral Tablet" }, { "code": "1087298", "display": "ascorbic acid 40 MG / ferrous fumarate 62.5 MG / folic acid 1 MG / niacin 3 MG / polysaccharide iron complex 62.5 MG Oral Capsule" }, { "code": "876858", "display": "ascorbic acid 35 MG/ML / cholecalciferol 0.01 MG/ML / niacin 8 MG/ML / riboflavin 0.6 MG/ML / thiamine 0.5 MG/ML / vitamin A 0.45 MG/ML / vitamin B12 0.002 MG/ML / vitamin B6 0.4 MG/ML / vitamin E 2.25 MG/ML Oral Solution" }, { "code": "876863", "display": "ascorbic acid 35 MG/ML / cholecalciferol 0.01 MG/ML / ferrous sulfate 50 MG/ML / niacin 8 MG/ML / riboflavin 0.6 MG/ML / thiamine 0.5 MG/ML / vitamin A 0.45 MG/ML / vitamin B6 0.4 MG/ML / vitamin E 2.25 MG/ML Oral Solution" }, { "code": "1234482", "display": "ascorbic acid 35 MG/ML / cholecalciferol 400 UNT/ML / niacin 8 MG/ML / riboflavin 0.6 MG/ML / sodium fluoride 0.55 MG/ML / thiamine 0.5 MG/ML / vitamin A 1500 UNT/ML / vitamin B12 0.002 MG/ML / vitamin B6 0.4 MG/ML / vitamin E 5 UNT/ML Oral Solution" }, { "code": "1659161", "display": "1 ML alirocumab 150 MG/ML Auto-Injector [Praluent]" }, { "code": "1659167", "display": "1 ML alirocumab 150 MG/ML Prefilled Syringe [Praluent]" }, { "code": "1659179", "display": "1 ML alirocumab 75 MG/ML Prefilled Syringe [Praluent]" }, { "code": "1659183", "display": "1 ML alirocumab 75 MG/ML Auto-Injector [Praluent]" }, { "code": "1659156", "display": "1 ML alirocumab 150 MG/ML Auto-Injector" }, { "code": "1659165", "display": "1 ML alirocumab 150 MG/ML Prefilled Syringe" }, { "code": "1659177", "display": "1 ML alirocumab 75 MG/ML Prefilled Syringe" }, { "code": "1659182", "display": "1 ML alirocumab 75 MG/ML Auto-Injector" }, { "code": "1665900", "display": "1 ML evolocumab 140 MG/ML Auto-Injector [Repatha]" }, { "code": "1665906", "display": "1 ML evolocumab 140 MG/ML Prefilled Syringe [Repatha]" }, { "code": "1801322", "display": "3.5 ML evolocumab 120 MG/ML Cartridge [Repatha]" }, { "code": "1665895", "display": "1 ML evolocumab 140 MG/ML Auto-Injector" }, { "code": "1665904", "display": "1 ML evolocumab 140 MG/ML Prefilled Syringe" }, { "code": "1801319", "display": "3.5 ML evolocumab 120 MG/ML Cartridge" }, { "code": "352304", "display": "ezetimibe 10 MG Oral Tablet [Zetia]" }, { "code": "1245420", "display": "ezetimibe 10 MG / simvastatin 10 MG Oral Tablet [Vytorin]" }, { "code": "1245430", "display": "ezetimibe 10 MG / simvastatin 20 MG Oral Tablet [Vytorin]" }, { "code": "1245441", "display": "ezetimibe 10 MG / simvastatin 40 MG Oral Tablet [Vytorin]" }, { "code": "1245449", "display": "ezetimibe 10 MG / simvastatin 80 MG Oral Tablet [Vytorin]" }, { "code": "2536060", "display": "ezetimibe 10 MG / rosuvastatin 10 MG Oral Tablet [Roszet]" }, { "code": "2536062", "display": "ezetimibe 10 MG / rosuvastatin 20 MG Oral Tablet [Roszet]" }, { "code": "2536064", "display": "ezetimibe 10 MG / rosuvastatin 40 MG Oral Tablet [Roszet]" }, { "code": "2536066", "display": "ezetimibe 10 MG / rosuvastatin 5 MG Oral Tablet [Roszet]" }, { "code": "2283236", "display": "bempedoic acid 180 MG / ezetimibe 10 MG Oral Tablet [Nexlizet]" }, { "code": "349556", "display": "ezetimibe 10 MG Oral Tablet" }, { "code": "476345", "display": "ezetimibe 10 MG / simvastatin 10 MG Oral Tablet" }, { "code": "476349", "display": "ezetimibe 10 MG / simvastatin 20 MG Oral Tablet" }, { "code": "476350", "display": "ezetimibe 10 MG / simvastatin 40 MG Oral Tablet" }, { "code": "476351", "display": "ezetimibe 10 MG / simvastatin 80 MG Oral Tablet" }, { "code": "2535745", "display": "ezetimibe 10 MG / rosuvastatin 20 MG Oral Tablet" }, { "code": "2535747", "display": "ezetimibe 10 MG / rosuvastatin 5 MG Oral Tablet" }, { "code": "2535749", "display": "ezetimibe 10 MG / rosuvastatin 40 MG Oral Tablet" }, { "code": "2535750", "display": "ezetimibe 10 MG / rosuvastatin 10 MG Oral Tablet" }, { "code": "2283230", "display": "bempedoic acid 180 MG / ezetimibe 10 MG Oral Tablet" } ], "system": "http://www.nlm.nih.gov/research/umls/rxnorm" } ] }, "description": "Medications for lowering cholesterol and hypertension", "experimental": true, "name": "Medication_records_required_for_people_heart_study", "publisher": "Harvard Medical School", "status": "draft", "title": "Medication records required for People Heart study", "url": "https://peoplepoweredmedicine.org/fhir/ValueSet/phs-medications", "version": "1.0", "resourceType": "ValueSet" }, { "id": "phs-observations", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareablevalueset" ] }, "text": { "div": "
List of observations used in People Heart Study
", "status": "generated" }, "compose": { "include": [ { "concept": [ { "code": "2345-7", "display": "Glucose" }, { "code": "2339-0", "display": "Glucose" }, { "code": "4548-4", "display": "HbA1c" }, { "code": "13457-7", "display": "LDL" }, { "code": "18262-6", "display": "LDL" }, { "code": "2089-1", "display": "LDL" }, { "code": "2085-9", "display": "HDL" }, { "code": "2093-3", "display": "Chol" }, { "code": "35200-5", "display": "Chol" }, { "code": "43396-1", "display": "Non-HDL Chol" }, { "code": "2571-8", "display": "Triglycerides" }, { "code": "3043-7", "display": "Triglycerides" }, { "code": "55284-4", "display": "BP" }, { "code": "72166-2", "display": "Smoking history" } ], "system": "http://loinc.org" } ] }, "description": "Lipid panel (Cholesterol, LDL-cholesterol, HDL-cholesterol, Triglycerides), Blood glucose, HbA1c, blood pressure and smoking history", "experimental": true, "name": "Observation_valuset_for_People_Heart_Study", "publisher": "Harvard Medical School", "status": "draft", "title": "Observation records required for People Heart study", "url": "https://peoplepoweredmedicine.org/fhir/ValueSet/phs-observations", "version": "1.0", "resourceType": "ValueSet" }, { "id": "Questionnaire-TotalCholesterol", "code": [ { "code": "2093-3", "display": "Cholesterol [Mass/volume] in Serum or Plasma", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "2093-3" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/maxValue", "valueDecimal": 320 }, { "url": "http://hl7.org/fhir/StructureDefinition/minValue", "valueDecimal": 100 }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-unit", "valueCoding": { "code": "mg/dl", "display": "mg/dL", "system": "http://unitsofmeasure.org" } } ], "code": [ { "code": "2093-3", "system": "http://loinc.org" } ], "linkId": "1", "required": true, "text": "What is your most recent total cholesterol level?", "type": "decimal" } ], "name": "TotalCholesterol", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Total Cholesterol", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-TotalCholesterol-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of Total Cholesterol", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-TotalCholesterol", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-TotalCholesterol", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-LDLCholesterol", "code": [ { "code": "18262-6", "display": "Cholesterol in LDL [Mass/volume] in Serum or Plasma by Direct assay", "system": "http://loinc.org" }, { "code": "13457-7", "display": "Cholesterol in LDL [Mass/volume] in Serum or Plasma by calculation", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "18262-6" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/maxValue", "valueDecimal": 300 }, { "url": "http://hl7.org/fhir/StructureDefinition/minValue", "valueDecimal": 30 }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-unit", "valueCoding": { "code": "mg/dl", "display": "mg/dL", "system": "http://unitsofmeasure.org" } } ], "code": [ { "code": "18262-6", "system": "http://loinc.org" } ], "linkId": "2", "required": true, "text": "What is your most recent LDL-cholesterol level?", "type": "decimal" } ], "name": "LDLCholesterol", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "LDL-cholesterol", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-LDLCholesterol-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of LDL Cholesterol", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-LDLCholesterol", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-LDLCholesterol", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-HDLCholesterol", "code": [ { "code": "2085-9", "display": "Cholesterol in HDL [Mass/volume] in Serum or Plasma", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "2085-9" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/maxValue", "valueDecimal": 100 }, { "url": "http://hl7.org/fhir/StructureDefinition/minValue", "valueDecimal": 20 }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-unit", "valueCoding": { "code": "mg/dl", "display": "mg/dL", "system": "http://unitsofmeasure.org" } } ], "code": [ { "code": "2085-9", "system": "http://loinc.org" } ], "linkId": "1", "required": true, "text": "What was your most recent HDL-cholesterol level?", "type": "decimal" } ], "name": "HDLcholesterol", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "HDL-cholesterol", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-HDLCholesterol-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of HDL Cholesterol", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-HDLCholesterol", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-HDLCholesterol", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-Triglyceride", "code": [ { "code": "2571-8", "display": "Triglyceride [Mass/volume] in Serum or Plasma", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "2571-8" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/maxValue", "valueDecimal": 400 }, { "url": "http://hl7.org/fhir/StructureDefinition/minValue", "valueDecimal": 10 }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-unit", "valueCoding": { "code": "mg/dl", "display": "mg/dL", "system": "http://unitsofmeasure.org" } } ], "code": [ { "code": "2571-8", "system": "http://loinc.org" } ], "linkId": "1", "required": true, "text": "What is your most recent triglyceride level?", "type": "decimal" } ], "name": "Triglycerides", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Triglycerides", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-Triglyceride-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of Triglyceride", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-Triglyceride", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-Triglyceride", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-Bloodpressure", "code": [ { "code": "55284-4", "display": "Blood pressure systolic and diastolic", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "55284-4" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "code": [ { "code": "55284-4", "system": "http://loinc.org" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/maxValue", "valueInteger": 200 }, { "url": "http://hl7.org/fhir/StructureDefinition/minValue", "valueInteger": 90 }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-unit", "valueCoding": { "code": "mm[Hg]", "display": "mm[Hg]", "system": "http://unitsofmeasure.org" } } ], "code": [ { "code": "55284-4", "system": "http://loinc.org" } ], "linkId": "sbp", "required": true, "text": "Systolic", "type": "integer" }, { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/maxValue", "valueInteger": 150 }, { "url": "http://hl7.org/fhir/StructureDefinition/minValue", "valueInteger": 30 }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-unit", "valueCoding": { "code": "mm[Hg]", "display": "mm[Hg]", "system": "http://unitsofmeasure.org" } } ], "code": [ { "code": "55284-4", "system": "http://loinc.org" } ], "linkId": "dbp", "required": true, "text": "Diastolic:", "type": "integer" } ], "linkId": "group", "required": true, "text": "What is your most recent blood pressure?", "type": "group" } ], "name": "BloodPressure", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Recent blood pressure", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-Bloodpressure-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of Blood pressure", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-Bloodpressure", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-Bloodpressure", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-HbA1c", "code": [ { "code": "4548-4", "display": "Hemoglobin A1c/Hemoglobin.total in Blood", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "4548-4" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/maxValue", "valueDecimal": 15 }, { "url": "http://hl7.org/fhir/StructureDefinition/minValue", "valueDecimal": 2 }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-unit", "valueCoding": { "code": "%", "display": "%", "system": "http://unitsofmeasure.org" } } ], "code": [ { "code": "4548-4", "system": "http://loinc.org" } ], "linkId": "2", "required": true, "text": "What is your most recent Hb-A1c level?", "type": "decimal" } ], "name": "HbA1c", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Hb A1c", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-HbA1c-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of HbA1c", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-HbA1c", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-HbA1c", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-Glucose", "code": [ { "code": "2345-7", "display": "Glucose [Mass/volume] in Serum or Plasma", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "2345-7" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/maxValue", "valueDecimal": 600 }, { "url": "http://hl7.org/fhir/StructureDefinition/minValue", "valueDecimal": 30 }, { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-unit", "valueCoding": { "code": "mg/dl", "display": "mg/dL", "system": "http://unitsofmeasure.org" } } ], "code": [ { "code": "2345-7", "system": "http://loinc.org" } ], "linkId": "1", "required": true, "text": "What is your most recent sugar (glucose) level?", "type": "decimal" } ], "name": "SerumGlucose", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Serum Glucose", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-Glucose-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of Glucose", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-Glucose", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-Glucose", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-Diabetesmellitus", "code": [ { "code": "44054006", "display": "Diabetes mellitus type II", "system": "http://snomed.info/sct" } ], "date": "2020-11", "identifier": [ { "system": "http://snomed.info/sct", "value": "44054006" }, { "system": "http://loinc.org", "value": "71482-4" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "linkId": "1", "required": true, "text": "Have you been diagnosed with high blood sugar or diabetes mellitus?", "type": "boolean" } ], "name": "Diabetes", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Diabetes", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-Diabetesmellitus-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of Diabetes mellitus", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-Diabetesmellitus", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-Diabetesmellitus", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-Hypertensionmedication", "code": [ { "code": "58293-2", "display": "Taken medication for high blood cholesterol", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "58293-2" } ], "item": [ { "code": [ { "code": "58293-2", "display": "Taken medication for high blood cholesterol", "system": "http://loinc.org" } ], "linkId": "2", "required": true, "text": "Are you taking any medication to lower blood-cholesterol?", "type": "boolean" } ], "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Medication for high blood cholesterol", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-Hypertensionmedication-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of Hypertension medication", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-Hypertensionmedication", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-Hypertensionmedication", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-Smokinghistory", "code": [ { "code": "72166-2", "display": "Tobacco smoking status", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://loinc.org", "value": "72166-2" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "answerOption": [ { "valueCoding": { "code": "current-smoker", "display": "Smoke every day or some days", "system": "http://dbmi.hms.harvard.edu/ppm/guidelines/smoking-status" } }, { "valueCoding": { "code": "former-smoker", "display": "Do not currently smoke and have been abstinent for the last 7 days", "system": "http://dbmi.hms.harvard.edu/ppm/guidelines/smoking-status" } }, { "valueCoding": { "code": "never-smoked", "display": "Never smoked regularly and do not currently smoke tobacco products", "system": "http://dbmi.hms.harvard.edu/ppm/guidelines/smoking-status" } } ], "linkId": "1", "required": true, "text": "Have you smoked cigarettes or other tobacco products?", "type": "choice" } ], "name": "Smokinghistory", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Smoking history", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "ActivityDefinition-Smokinghistory-survey", "text": { "div": "
Activity Definition of a survey
", "status": "generated" }, "description": "Activity Definition of Smoking history", "experimental": true, "kind": "Task", "name": "Definition_Task2_SubAction", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-Smokinghistory", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task2-Smokinghistory", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Definition-RiskFactors-family-history", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition of risk enhancing questionnaire task
", "status": "generated" }, "description": "Definition of survey for Family history of premature heart disease", "experimental": true, "kind": "Task", "name": "Definition_Task3_riskfactors_familyhistory", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#family-history", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task3-riskfactors-family-history", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Definition-RiskFactors-chronicConditions", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition of risk enhancing questionnaire task
", "status": "generated" }, "description": "Definition of survey for Chronic Conditions", "experimental": true, "kind": "Task", "name": "Definition_Task3_riskfactors_chronicConditions", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#chronicConditions", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task3_riskfactors-chronicConditions", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Definition-RiskFactors-female-riskfactors", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition of risk enhancing questionnaire task
", "status": "generated" }, "description": "Definition of survey for Risk Factors Survey", "experimental": true, "kind": "Task", "name": "Definition_Task3_riskfactors_femaleriskfactors", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#female-riskfactors", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task3_riskfactors-female-riskfactors", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Definition-RiskFactors-southasianethnicity", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition of risk enhancing questionnaire task
", "status": "generated" }, "description": "Definition of survey for Southasian ethnicity", "experimental": true, "kind": "Task", "name": "Definition_Task3_riskfactors_southasianethnicitiy", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#southasianethnicity", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task3_riskfactors-southasianethnicity", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Definition-RiskFactors-chronicKidneyDisease", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition of risk enhancing questionnaire task
", "status": "generated" }, "description": "Definition of survey for Chronic kidney disease", "experimental": true, "kind": "Task", "name": "Definition_Task3_riskfactors_chronicKidneyDisease", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "resource": "#chronicKidneyDisease", "type": "depends-on" } ], "status": "active", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task3_riskfactors-chronicKidneyDisease", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "family-history", "meta": { "profile": [ "http://hl7.org/fhir/4.0/StructureDefinition/Questionnaire" ] }, "text": { "div": "
Survey about family history of premature cardiovascular disease
", "status": "generated" }, "code": [ { "code": "80985-5", "display": "Family history of Premature coronary artery disease", "system": "http://loinc.org" } ], "date": "2020-11", "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "familyHistoryOfPrematureCVD" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-instruction", "valueString": "People with a parent or a sibling who have had a cardiovascular event (like heart attack or stroke) before the age of 55 years in men or 65 years in women, are likely to be at higher risk of developing heart disease." } ], "code": [ { "code": "80985-5", "display": "Family history of Premature coronary artery disease", "system": "http://loinc.org" } ], "linkId": "01", "text": "Do you have a parent or sibling who have had a heart attack or stroke or other cardiovascular event before the age of 55 years in men or 65 years in women?", "type": "boolean" } ], "status": "draft", "title": "Family history of premature heart disease", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "chronicConditions", "meta": { "profile": [ "http://hl7.org/fhir/4.0/StructureDefinition/Questionnaire" ] }, "text": { "div": "
Chronic conditions survey as part of the People Heart Study from Harvard Medical School
", "status": "generated" }, "date": "2020-11", "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "chronicConditions" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-instruction", "valueString": "Some chronic inflammatory conditions can be risk factors for developing heart disease." } ], "answerOption": [ { "valueCoding": { "code": "69896004", "display": "Rheumatoid arthritis", "system": "http://snomed.info/sct" } }, { "valueCoding": { "code": "9014002", "display": "Psoriasis", "system": "http://snomed.info/sct" } }, { "valueCoding": { "code": "55464009", "display": "SLE - Systemic lupus erythematosus", "system": "http://snomed.info/sct" } }, { "valueCoding": { "code": "89155008", "display": "Systemic Sclerosis", "system": "http://snomed.info/sct" } }, { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-optionExclusive", "valueBoolean": true } ], "valueCoding": { "code": "none", "display": "None", "system": "http://dbmi.hms.harvard.edu/fhir/vs-answerChoice" } } ], "code": [ { "code": "chronicConditions", "display": "Chronic Conditions", "system": "http://dbmi.hms.harvard.edu" } ], "linkId": "chronicConditions", "repeats": true, "text": "Have you been diagnosed with any of the following conditions?", "type": "open-choice" } ], "status": "draft", "title": "Chronic Conditions", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "female-riskfactors", "meta": { "profile": [ "http://hl7.org/fhir/4.0/StructureDefinition/Questionnaire" ] }, "text": { "div": "
Survey about female-specific conditions for the People Heart Study
", "status": "generated" }, "code": [ { "code": "femaleriskfactors", "system": "http://dbmi.hms.harvard.edu" } ], "date": "2020-11", "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "femaleriskfactors" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-instruction", "valueString": "History of premature menopause (before age 40 y) and history of pregnancy-associated conditions such as preeclampsia can increase the risk of atherosclerotic cardiovascular disease." } ], "item": [ { "code": [ { "code": "106005003", "display": "Hypertension AND/OR vomiting complicating pregnancy childbirth AND/OR puerperium (disorder)", "system": "http://snomed.info/sct" }, { "code": "111438007", "display": "Hypertension secondary to renal disease in obstetric context (disorder)", "system": "http://snomed.info/sct" }, { "code": "198942000", "display": "Benign essential hypertension complicating pregnancy, childbirth and the puerperium (disorder)", "system": "http://snomed.info/sct" }, { "code": "198944004", "display": "Benign essential hypertension complicating pregnancy, childbirth and the puerperium - 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delivered with postnatal complication (disorder)", "system": "http://snomed.info/sct" }, { "code": "198985009", "display": "Severe pre-eclampsia - not delivered (disorder)", "system": "http://snomed.info/sct" }, { "code": "198986005", "display": "Severe pre-eclampsia with postnatal complication (disorder)", "system": "http://snomed.info/sct" }, { "code": "198990007", "display": "Eclampsia - delivered (disorder)", "system": "http://snomed.info/sct" }, { "code": "198991006", "display": "Eclampsia - delivered with postnatal complication (disorder)", "system": "http://snomed.info/sct" }, { "code": "198992004", "display": "Eclampsia in pregnancy (disorder)", "system": "http://snomed.info/sct" }, { "code": "198993009", "display": "Eclampsia with postnatal complication (disorder)", "system": "http://snomed.info/sct" }, { "code": "198997005", "display": "Pre-eclampsia or eclampsia with pre-existing hypertension (disorder)", "system": "http://snomed.info/sct" }, { "code": "198999008", "display": "Pre-eclampsia or eclampsia with pre-existing hypertension - delivered (disorder)", "system": "http://snomed.info/sct" }, { "code": "199000005", "display": "Pre-eclampsia or eclampsia with pre-existing hypertension - delivered with postnatal complication (disorder)", "system": "http://snomed.info/sct" }, { "code": "199002002", "display": "Pre-eclampsia or eclampsia with pre-existing hypertension - not delivered (disorder)", "system": "http://snomed.info/sct" }, { "code": "199003007", "display": "Pre-eclampsia or eclampsia with pre-existing hypertension with postnatal complication (disorder)", "system": "http://snomed.info/sct" }, { "code": "199006004", "display": "Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium (disorder)", "system": "http://snomed.info/sct" }, { "code": "237279007", "display": "Transient hypertension of pregnancy (disorder)", "system": "http://snomed.info/sct" }, { "code": "237281009", "display": "Moderate proteinuric hypertension of pregnancy (disorder)", "system": "http://snomed.info/sct" }, { "code": "237282002", "display": "Impending eclampsia (disorder)", "system": "http://snomed.info/sct" }, { "code": "237283007", "display": "Eclampsia in labor (disorder)", "system": "http://snomed.info/sct" }, { "code": "288250001", "display": "Maternal hypertension (disorder)", "system": "http://snomed.info/sct" }, { "code": "303063000", "display": "Eclampsia in puerperium (disorder)", "system": "http://snomed.info/sct" }, { "code": "307632004", "display": "Non-proteinuric hypertension of pregnancy (disorder)", "system": "http://snomed.info/sct" }, { "code": "367390009", "display": "Hypertension in the obstetric context (disorder)", "system": "http://snomed.info/sct" }, { "code": "398254007", "display": "Pre-eclampsia (disorder)", "system": "http://snomed.info/sct" }, { "code": "429457004", "display": "Systolic essential hypertension (disorder)", "system": "http://snomed.info/sct" }, { "code": "698638005", "display": "Pregnancy induced hypertension with pulmonary edema (disorder)", "system": "http://snomed.info/sct" }, { "code": "698640000", "display": "Hypertension in the puerperium with pulmonary edema (disorder)", "system": "http://snomed.info/sct" }, { "code": "762463000", "display": "Diastolic hypertension co-occurrent with systolic hypertension (disorder)", "system": "http://snomed.info/sct" }, { "code": "765182005", "display": "Pre-eclampsia in puerperium (disorder)", "system": "http://snomed.info/sct" }, { "code": "541000119105", "display": "Hypertension complicating pregnancy, childbirth and the puerperium, antepartum (disorder)", "system": "http://snomed.info/sct" }, { "code": "40511000119107", "display": "Postpartum pre-existing essential hypertension (disorder)", "system": "http://snomed.info/sct" }, { "code": "82771000119102", "display": "Hypertension complicating pregnancy (disorder)", "system": "http://snomed.info/sct" }, { "code": "118781000119108", "display": "Pre-existing hypertensive chronic kidney disease in mother complicating pregnancy (disorder)", "system": "http://snomed.info/sct" }, { "code": "10752641000119102", "display": "Eclampsia with pre-existing hypertension in childbirth (disorder)", "system": "http://snomed.info/sct" }, { "code": "10757481000119107", "display": "Pre-existing hypertensive heart and chronic kidney disease in mother complicating pregnancy (disorder)", "system": "http://snomed.info/sct" }, { "code": "10759031000119106", "display": "Pre-existing hypertensive heart disease in mother complicating pregnancy (disorder)", "system": "http://snomed.info/sct" } ], "linkId": "25", "text": "Do you have a history of pre-eclampsia in the past (a condition that can arise in pregnancy)?", "type": "boolean" }, { "linkId": "note", "text": "History of premature menopause (before age 40 y) and history of pregnancy-associated conditions such as preeclampsia can increase the risk of atherosclerotic cardiovascular disease.", "type": "display" }, { "code": [ { "code": "373717006", "display": "Premature menopause", "system": "http://snomed.info/sct" } ], "linkId": "26", "text": "Do you have a history of menopause before the age of 40?", "type": "boolean" } ], "linkId": "25.1", "required": false, "type": "group" } ], "status": "draft", "title": "Risk Factors Survey", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "southasianethnicity", "meta": { "profile": [ "http://hl7.org/fhir/4.0/StructureDefinition/Questionnaire" ] }, "text": { "div": "
Survey about south asian ancestry as part of the People Heart Study from Harvard Medical School
", "status": "generated" }, "date": "2020-11", "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "southasianethnicity" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-instruction", "valueString": "Studies have found individuals of South Asian ancestry to be at higher risk of developing a cardiovascular event (like heart attack or stroke)." } ], "code": [ { "code": "186044009", "display": "South East Asian (ethnic group)", "system": "http://snomed.info/sct" } ], "linkId": "02", "text": "Do you identify as being of South Asian ancestry?", "type": "boolean" } ], "status": "draft", "title": "Southasian ethnicity", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "chronicKidneyDisease", "meta": { "profile": [ "http://hl7.org/fhir/4.0/StructureDefinition/Questionnaire" ] }, "text": { "div": "
Survey about chronic kidney disease as part of the People Heart Study from Harvard Medical School
", "status": "generated" }, "code": [ { "code": "709044004", "display": "Chronic kidney disease", "system": "http://snomed.info/sct" } ], "date": "2020-11", "identifier": [ { "system": "http://snomed.info/sct", "value": "709044004" }, { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-instruction", "valueString": "Chronic kidney disease can raise the risk of developing heart attack or stroke or other cardiovascular event." } ], "linkId": "1", "required": false, "text": "Have you been diagnosed with chronic kidney disease but have not had dialysis or transplant?", "type": "boolean" } ], "name": "Questionnaire_Chronic_kidney_disease", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Chronic kidney disease", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "definition-recommendation", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition task 4 of the People Heart Study. Requires Device (PHS APP) for execution
", "status": "generated" }, "code": { "coding": [ { "code": "riskandrecommendation", "system": "http://dbmi.hms.harvard.edu" } ] }, "description": "Definition of a task as part of a study participation activity for People Heart study", "experimental": true, "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "riskandrecommendation" } ], "kind": "Task", "name": "Definiton_Recommendations_Task4", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task as part of a study participation activity for People Heart study", "relatedArtifact": [ { "display": "This task can be executed only in the People Heart Study iOS app", "label": "People Heart Study app", "resource": "#device-people-heart-study-app", "type": "depends-on", "url": "https://apps.apple.com/us/app/people-heart-study/id1591183594" } ], "status": "active", "title": "Guideline-supported Recommendations to control blood cholesterol and prevent heart attack, stroke or other cardiovascular event", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task4", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "device-people-heart-study-app", "text": { "div": "
Device representing the People Heart Study app
", "status": "generated" }, "contact": [ { "system": "url", "value": "https://peoplepoweredmedicine.org/heart" } ], "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "people-heart-study-app" } ], "manufacturer": "Harvard Medical School", "status": "active", "type": { "coding": [ { "code": "706689003", "display": "Application program software", "system": "http://snomed.info/sct" } ] }, "url": "https://apps.apple.com/us/app/people-heart-study/id1591183594", "resourceType": "Device" }, { "id": "definition-followup-survey", "meta": { "profile": [ "http://hl7.org/fhir/StructureDefinition/shareableactivitydefinition" ] }, "text": { "div": "
Definition task 5 of the People Heart Study.
", "status": "generated" }, "description": "Definition of a task to take a follow-up survey", "experimental": true, "kind": "ServiceRequest", "name": "Definition_followUp_survey", "participant": [ { "type": "patient" } ], "publisher": "Dept of Biomedical Informatics, Harvard Medical School", "purpose": "Definition of a task to take a follow-up survey for People Heart study", "relatedArtifact": [ { "resource": "#Questionnaire-followup-survey", "type": "depends-on" } ], "status": "active", "subtitle": "Please take a follow-up survey after you have had a discussion with your doctor", "title": "Follow-up survey", "url": "http://peoplepoweredmedicine.org/fhir/ActivityDefinition/peopleheartstudy-task5", "version": "1.1", "resourceType": "ActivityDefinition" }, { "id": "Questionnaire-followup-survey", "meta": { "profile": [ "http://hl7.org/fhir/4.0/StructureDefinition/Questionnaire" ] }, "text": { "div": "
This is a follow-up survey as part of the People Heart Study from Harvard Medical School
", "status": "generated" }, "code": [ { "code": "followup-survey", "display": "Follow-up survey", "system": "http://dbmi.hms.harvard.edu" } ], "copyright": "Harvard Medical School", "date": "2021-12-09T16:09:37.429Z", "description": "This survey will ascertain the impact of the recommendations made by this app.", "experimental": true, "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "use": "usual", "value": "ppm-guidelines-ascvd-study-statinrecommended-statinfound" }, { "system": "http://dbmi.hms.harvard.edu", "use": "usual", "value": "followup-survey" } ], "item": [ { "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/questionnaire-instruction", "valueString": "Based on your medical history and lab results, a cholesterol lowering medication is recommended to reduce the risk of developing a heart attack, stroke or other cardiovascular event.\n\nYou are not currently on this medication." } ], "linkId": "did_you_discuss", "required": true, "text": "Did you discuss the recommendations provided by this app with your doctor?", "type": "boolean" }, { "answerOption": [ { "valueCoding": { "code": "prescribed-statin", "display": "Yes, I was prescribed a statin to lower cholesterol", "system": "http://dbmi.hms.harvard.edu/ppm/guidelines/practitionerDiscussion" } }, { "valueCoding": { "code": "prescribed-other", "display": "Yes, I was prescribed another medication to lower cholesterol", "system": "http://dbmi.hms.harvard.edu/ppm/guidelines/practitionerDiscussion" } }, { "valueCoding": { "code": "notPrescribed", "display": "No, I was not prescribed any medication to lower cholesterol", "system": "http://dbmi.hms.harvard.edu/ppm/guidelines/practitionerDiscussion" } } ], "enableBehavior": "all", "enableWhen": [ { "answerBoolean": true, "operator": "=", "question": "did_you_discuss" } ], "linkId": "discussion_result", "required": true, "text": "Were you then prescribed a medication to lower blood cholesterol?", "type": "choice" }, { "enableWhen": [ { "answerCoding": { "code": "notPrescribed", "system": "http://dbmi.hms.harvard.edu/ppm/guidelines/practitionerDiscussion" }, "operator": "=", "question": "discussion_result" } ], "linkId": "discussion_result_explain_why", "required": false, "text": "Can you tell us why?", "type": "text" }, { "enableBehavior": "all", "enableWhen": [ { "answerBoolean": false, "operator": "=", "question": "did_you_discuss" } ], "linkId": "will.discuss.with.care.provider", "required": true, "text": "Would you be willing to discuss these recommendations with your doctor in the near future?", "type": "boolean" }, { "enableBehavior": "all", "enableWhen": [ { "answerBoolean": true, "operator": "=", "question": "will.discuss.with.care.provider" } ], "linkId": "final.reminding", "text": "Thank you.\n\nWe will remind you to take this survey after you have had a discussion with your doctor.", "type": "display" }, { "enableBehavior": "any", "enableWhen": [ { "answerBoolean": true, "operator": "!=", "question": "will.discuss.with.care.provider" } ], "linkId": "final", "text": "Thank you for completing this survey", "type": "display" } ], "name": "FollowUp_survey", "publisher": "Harvard Medical School", "status": "draft", "subjectType": [ "Patient", "Person" ], "title": "Follow up survey", "version": "1.0", "resourceType": "Questionnaire" }, { "id": "protocol-people-heart-study", "text": { "div": "
People Heart Study task activities
", "status": "generated" }, "action": [ { "id": "demographics-survey", "definitionCanonical": "#definition-demographic-survey", "title": "Demographic information" }, { "id": "clinical-records", "action": [ { "id": "Action-AD-HealthRecords", "definitionCanonical": "#AD-HealthRecords", "output": [ { "codeFilter": [ { "searchParam": "code", "valueSet": "#phs-observations" } ], "subjectCodeableConcept": { "coding": [ { "code": "Patient", "display": "Patient", "system": "http://hl7.org/fhir/resource-types" } ] }, "type": "Observation" }, { "codeFilter": [ { "searchParam": "code", "valueSet": "#phs-conditions" } ], "subjectCodeableConcept": { "coding": [ { "code": "Patient", "display": "Patient", "system": "http://hl7.org/fhir/resource-types" } ] }, "type": "Condition" }, { "codeFilter": [ { "searchParam": "code", "valueSet": "#phs-medications" } ], "subjectCodeableConcept": { "coding": [ { "code": "Patient", "display": "Patient", "system": "http://hl7.org/fhir/resource-types" } ] }, "type": "MedicationRequest" }, { "codeFilter": [ { "searchParam": "code", "valueSet": "#phs-medications" } ], "subjectCodeableConcept": { "coding": [ { "code": "Patient", "display": "Patient", "system": "http://hl7.org/fhir/resource-types" } ] }, "type": "Medication" } ], "title": "Getting health records" }, { "id": "Action-conditional-input-survey-TotalCholesterol", "condition": [ { "expression": { "expression": "not exists(Total Cholesterol)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-TotalCholesterol-survey", "title": "Total Cholesterol survey" }, { "id": "Action-conditional-input-survey-LDLCholesterol", "condition": [ { "expression": { "expression": "not exists(LDL Cholesterol)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-LDLCholesterol-survey", "title": "LDL Cholesterol survey" }, { "id": "Action-conditional-input-survey-HDLCholesterol", "condition": [ { "expression": { "expression": "not exists(HDL Cholesterol)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-HDLCholesterol-survey", "title": "HDL Cholesterol survey" }, { "id": "Action-conditional-input-survey-Triglyceride", "condition": [ { "expression": { "expression": "not exists(Triglyceride)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-Triglyceride-survey", "title": "Triglyceride survey" }, { "id": "Action-conditional-input-survey-Bloodpressure", "condition": [ { "expression": { "expression": "not exists(Blood pressure)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-Bloodpressure-survey", "title": "Blood pressure survey" }, { "id": "Action-conditional-input-survey-HbA1c", "condition": [ { "expression": { "expression": "not exists(HbA1c)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-HbA1c-survey", "title": "HbA1c survey" }, { "id": "Action-conditional-input-survey-Glucose", "condition": [ { "expression": { "expression": "not exists(Glucose)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-Glucose-survey", "title": "Glucose survey" }, { "id": "Action-conditional-input-survey-Diabetesmellitus", "condition": [ { "expression": { "expression": "not exists(Diabetes mellitus)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-Diabetesmellitus-survey", "title": "Diabetes mellitus survey" }, { "id": "Action-conditional-input-survey-Hypertensionmedication", "condition": [ { "expression": { "expression": "not exists(Hypertension medication)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-Hypertensionmedication-survey", "title": "Hypertension medication survey" }, { "id": "Action-conditional-input-survey-Smokinghistory", "condition": [ { "expression": { "expression": "not exists(Smoking history)", "language": "text/fhirpath" }, "kind": "applicability" } ], "definitionCanonical": "#ActivityDefinition-Smokinghistory-survey", "title": "Smoking history survey" } ], "relatedAction": [ { "actionId": "demographics-survey", "relationship": "after-end" } ], "title": "Getting health records" }, { "id": "risk-enhancers", "action": [ { "id": "Action-Definition-RiskFactors-family-history", "definitionCanonical": "#Definition-RiskFactors-family-history" }, { "id": "Action-Definition-RiskFactors-southasianethnicity", "definitionCanonical": "#Definition-RiskFactors-southasianethnicity" }, { "id": "Action-Definition-RiskFactors-chronicConditions", "definitionCanonical": "#Definition-RiskFactors-chronicConditions" }, { "id": "Action-Definition-RiskFactors-chronicKidneyDisease", "definitionCanonical": "#Definition-RiskFactors-chronicKidneyDisease" }, { "id": "Action-Definition-RiskFactors-female-riskfactors", "condition": [ { "expression": { "expression": "QuestionnaireResponse.item.where(linkId = \"/54126-8/54131-8\").answer.value", "language": "text/fhirpth" }, "kind": "applicability" } ], "definitionCanonical": "#Definition-RiskFactors-female-riskfactors" } ], "description": "Answer a series of questions to identify additional risk factors for developing heart attack, stroke or other cardiovascular event.", "relatedAction": [ { "actionId": "clinical-records", "relationship": "after-end" } ], "title": "Risk factors survey" }, { "id": "risk-recommendation", "definitionCanonical": "#definition-recommendation", "relatedAction": [ { "actionId": "risk-enhancers", "relationship": "after-end" } ], "title": "Guideline-supported Recommendations to control blood cholesterol and prevent heart attack, stroke or other cardiovascular event" }, { "id": "followup-survey", "condition": [ { "expression": { "expression": "MedicationRequest?identifier=dbmi", "language": "application/x-fhir-query" }, "kind": "applicability" } ], "definitionCanonical": "#definition-followup-survey", "relatedAction": [ { "actionId": "risk-recommendation", "offsetDuration": { "code": "d", "system": "http://unitsofmeasure.org", "value": 30 }, "relationship": "after-end" } ], "title": "Follow-up survey" } ], "name": "PeopleHeartStudy_Protocol", "status": "draft", "title": "Protocol of People Heart study", "resourceType": "PlanDefinition" } ], "condition": [ { "text": "Healthy subjects" } ], "contact": [ { "name": "Cassandra Perry", "telecom": [ { "system": "phone", "value": "(617)-432-5484" }, { "system": "email", "value": "ppm@hms.harvard.edu" } ] } ], "description": "This study will asssess if you can use your health data, from your care provider, to reliably estimate the risk of developing a heart attack, stroke or other cardiovascular event.", "enrollment": [ { "reference": "#enrollmentgroup" } ], "identifier": [ { "system": "http://dbmi.hms.harvard.edu", "value": "ppm-guidelines-ascvd-study" } ], "keyword": [ { "coding": [ { "code": "468361000124104", "display": "Assessment of risk for atherosclerotic cardiovascular disease", "system": "http://snomed.info/sct" }, { "code": "84698008", "display": "Cholesterol", "system": "http://snomed.info/sct" }, { "code": "440358008", "display": "Primary prevention of cardiovascular disease", "system": "http://snomed.info/sct" } ] }, { "text": "ASCVD" } ], "note": [ { "text": "
\n

About this study

This study will estimate your risk of developing a heart attack, stroke, or other cardiovascular event due to the buildup of cholesterol in your blood.

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We will use your health records stored on your iPhone and medical history to recommend lifestyle advice and if you benefit from medication to lower blood cholesterol and prevent developing a cardiovascular event in the future.

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Recommendations are based on guidelines published by the American College of Cardiology and American Heart Association.

\n" }, { "text": "

How this study works

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After confirming eligibility through this app, you will be presented with a list of 4 steps to complete.

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These steps consist of short surveys on your medical history and relevant risk factors for heart disease. We will also ask your permission to retrieve select data from your iPhone's Apple Health app.

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We estimate it should take no more than 30 minutes in total to complete all the steps in this research study.

\n\n
\n" }, { "text": "

What will this mean for me?

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Once all steps are completed, you will be able to view and download a recommendations report that can be shared with your doctor.

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This report will include information on your estimated risk of developing heart disease, related lab tests and medical history, lifestyle recommendations and if you require a medication, as appropriate.

\n" }, { "text": "

Why are we conducting this study?

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Heart disease is the leading cause of death in the United States.

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With appropriate lifestyle and medical management, heart disease can be prevented.

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This study will help us better understand your access to health data and how that can empower you with information on current guidelines to prevent heart disease.

\n\n" }, { "text": "

About us

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This study is conducted by the Department of Biomedical Informatics at Harvard Medical School led by Prof. Isaac Kohane, MD, PhD and the People Powered Medicine group. Learn more about our work:

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People Heart Study

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Department of Biomedical Informatics

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Contact us ppm@hms.harvard.edu

\n" } ], "objective": [ { "name": "Primary Objective", "type": { "coding": [ { "code": "primary", "display": "Primary", "system": "http://terminology.hl7.org/CodeSystem/research-study-objective-type" } ], "text": "This study will assess the completeness of health data obtained electronically through the use of SMART on FHIR application programming interface (API)." } }, { "name": "Secondary Objective", "type": { "coding": [ { "code": "secondary", "display": "Secondary", "system": "http://terminology.hl7.org/CodeSystem/research-study-objective-type" } ], "text": "Based on your data, we will assess if you are currently on recommended therapy for the primary prevention of cardiovascular disease, specifically the use of Statin medications" } } ], "period": { "start": "2024-01-01" }, "primaryPurposeType": { "coding": [ { "code": "screening", "display": "SCREENING", "system": "http://terminology.hl7.org/CodeSystem/research-study-prim-purp-type" }, { "code": "health-services-research", "display": "Health Services Research", "system": "http://terminology.hl7.org/CodeSystem/research-study-prim-purp-type" } ] }, "principalInvestigator": { "reference": "#PI-PeopleHeartStudy" }, "protocol": [ { "display": "People Heart Study protocol", "reference": "#protocol-people-heart-study" } ], "relatedArtifact": [ { "display": "People heart study home page", "type": "documentation", "url": "https://peoplepoweredmedicine.org/heart" }, { "display": "People heart study app link", "type": "depends-on", "url": "https://bit.ly/people-heart-study" } ], "sponsor": { "reference": "#hms-organization" }, "status": "active", "title": "People Heart Study", "resourceType": "ResearchStudy" } } ] }