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RANT Study

“RANT” stands for Rheumatoid Arthritis Non-responders to Treatments.

We are interested in understanding why rheumatoid arthritis (RA) therapies work for some patients and not others. In this study, we would like to hear from RA patients who have tried two or more biologic and targeted therapies and to obtain more information on why they did not work. Please see below for a list of the RA biologic and targeted therapies.

Many conditions are being redefined as scientific advancements improve our ability to study underlying genetics and pathways. Studying RA patients who do not respond to biologic therapy will help us to understand why you may be different and help us to discover different pathways to target for therapy. In turn, this can inform our ability to treat patients with RA with more precision medicine and ultimately improve the management and lives of patients with inflammatory arthritis in the future.

Who Can Volunteer

Non-responders include RA patients who had active disease despite receiving at least two of the following biologic or targeted RA therapies:

  • tocilizumab (Actemra)
  • certolizumab (Cimzia)
  • etanercept (Enbrel)
  • adalimumab (Humira)
  • sarilumab (Kevzara)
  • anakinra (Kineret)
  • baricitinib (Olumiant)
  • abatacept (Orencia)
  • infliximab (Remicade)
  • upadacitinib (Rinvoq)
  • rituximab (Rituxan)
  • golimumab (Simponi)
  • tofacitinib (Xeljanz)
Illustration: Hand with rheumatoid arthritis in joints

Non-responder to RA treatment (as described above)

Illustration: Continental United States

Living in the United States

Illustration: Birthday cake with 18 candles

Age 18 or older

Illustration: 100 people in PPM color spectrum

One of the first 300 people to enroll

Enroll Now

What to Expect

Here's what participation in the study involves.

Illustration: Enrollment confirmation and participation consent

Register via email and give a brief description of your experience with treatments for your rheumatoid arthritis.

Illustration: Online questionnaire completion

Complete an online questionnaire about your health history.

Illustration: Medical record access

Give access to your medical records.

Illustration: DNA sample collection

Collect blood samples for genetic testing.

Research Team

RANT is a collaboration between the People-Powered Medicine team at DBMI and our partners at Brigham and Women's Hospital:

Katherine Liao

Katherine Liao

Mary Jeffway

Mary Jeffway

Gregory McDermott

Gregory McDermott

Dana Weisenfeld

Dana Weisenfeld

Harrison Zhang

Harrison Zhang